Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials (2024)

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BMJ open

Randomised controlled trial of exercise to prevent shoulder problems in women undergoing breast cancer treatment: study protocol for the prevention of shoulder problems trial (UK PROSPER)

2018 •

Sarah Lamb

Musculoskeletal shoulder problems are common after breast cancer treatment. Early postoperative exercises targeting the upper limb may improve shoulder function. This protocol describes a National Institute for Health Research-funded randomised controlled trial (RCT) to evaluate the clinical and cost-effectiveness of an early supervised structured exercise programme compared with usual care, for women at high risk of developing shoulder problems after breast cancer surgery. This pragmatic two-armed, multicentre RCT is underway within secondary care in the UK. PRevention Of Shoulder ProblEms tRial (PROSPER) aims to recruit 350 women from approximately 15 UK centres with follow-up at 6 weeks, 6 and 12 months after randomisation. Recruitment processes and intervention development were optimised through qualitative research during a 6-month internal pilot phase. Participants are randomised to the PROSPER intervention or best practice usual care only. The PROSPER intervention is delivere...

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BMC health services research

Development of an exercise intervention for the prevention of musculoskeletal shoulder problems after breast cancer treatment: the prevention of shoulder problems trial (UK PROSPER)

2018 •

meredith newman

Musculoskeletal shoulder problems are common after breast cancer treatment. There is some evidence to suggest that early postoperative exercise is safe and may improve shoulder function. We describe the development and delivery of a complex intervention for evaluation within a randomised controlled trial (RCT), designed to target prevention of musculoskeletal shoulder problems after breast cancer surgery (The Prevention of Shoulder Problems Trial; PROSPER). A pragmatic, multicentre RCT to compare the clinical and cost-effectiveness of best practice usual care versus a physiotherapy-led exercise and behavioural support intervention in women at high risk of shoulder problems after breast cancer treatment. PROSPER will recruit 350 women from approximately 15 UK centres, with follow-up at 6 and 12 months. The primary outcome is shoulder function at 12 months; secondary outcomes include postoperative pain, health related quality of life, adverse events and healthcare resource use. A mult...

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Author’s response to reviews Title: Mediating effects of shoulder-arm exercise on the postoperative severity of symptoms and quality of life of women with breast cancer Authors

2020 •

Chia-Hui Wang

Title: Mediating effects of shoulder-arm exercise on the postoperative severity of symptoms and quality of life of women with breast cancer Authors: I-Hui Chen (ichen4@tmu.edu.tw) Chia-Hui Wang (wangch@tmu.edu.tw) Shu-Yi Wang (swang@regis.edu) Sue-Yueh Cheng (sycheng@tmu.edu.tw) Tzu-Jou Yu (ee56073@tmu.edu.tw) Shu-Fen Kuo (sfkuo6@tmu.edu.tw) Version: 1 Date: 23 Apr 2020 Author’s response to reviews: Manuscript ID: BMWH-D-20-00136 Title: Mediating effects of shoulder-arm exercise on the postoperative severity of symptoms and quality of life of women with breast cancer April 6, 2020 Dear reviewers and editors, Thank you for your thoughtful and insightful comments about our article. We revised the manuscript to reflect the reviewers’ and your suggestions. The revised manuscript is attached (revisions are in red type), and the revisions are summarized below:

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BMC Women's Health

Mediating effects of shoulder-arm exercise on the postoperative severity of symptoms and quality of life of women with breast cancer

2020 •

Shu-Fen Kuo

Background The postoperative severity of symptoms among women with breast cancer affects their quality of life (QoL). Although it is recommended that performing shoulder-arm exercise 30 min/day can alleviate symptoms and improve the QoL, there is little research on the mediating effects of performing shoulder-arm exercise 30 min/day on the postoperative severity of symptoms and QoL among patients with breast cancer. Methods A cross-sectional study was conducted 2 ~ 4 months after surgery on women diagnosed with breast cancer but with no distant metastasis and who had undergone breast cancer surgery for the first time. A structured questionnaire was employed which included a severity of symptoms scale, performing shoulder-arm exercise for 30 min/day, a QoL scale, demographic characteristics, and medical status. Results In total, 117 women with breast cancer completed the survey. The severity of symptoms and performing shoulder-arm exercise 30 min/day separately affected the QoL (B = ...

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Critical Reviews in Physical and Rehabilitation Medicine

Efficacy of Physical Therapy Methods and Exercise After a Breast Cancer Operation: A Systematic Review

2001 •

Anne Kärki

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Physical Therapy

Aerobic and Resistance Exercise Improves Shoulder Function in Women Who Are Overweight or Obese and Have Breast Cancer: A Randomized Controlled Trial

2019 •

Kimiko Yamada

Abtract Background Adverse upper limb musculoskeletal effects occur after surgical procedures and radiotherapy for breast cancer and can interfere with activities of daily living. Objective The objective of this study was to examine the effects of a 16-week exercise intervention on shoulder function in women who are overweight or obese and have breast cancer. Design This study was a randomized controlled trial. Setting The study was performed at the Division of Biokinesiology and Physical Therapy at the University of Southern California. Participants One hundred women with breast cancer were randomly allocated to exercise or usual-care groups. The mean (SD) age of the women was 53.5 (10.4) years, 55% were Hispanic white, and their mean (SD) body mass index was 33.5 (5.5) kg/m2. Intervention The 16-week exercise intervention consisted of supervised, progressive, moderate to vigorous aerobic and resistance exercise 3 times per week. Measurements Shoulder active range of motion, isomet...

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https://www.ijhsr.org/IJHSR_Vol.12_Issue.3_March2022/IJHSR-Abstract.018.html

A Case Report on the Impact of Physiotherapy on Shoulder Function in Breast Cancer Patients Undergoing Surgery

2022 •

International Journal of Health Sciences and Research (IJHSR)

Early breast cancer treatment can cause shoulder dysfunction, which is a well-known and prevalent adverse effect (1). In individuals treated surgically for breast cancer, physiotherapy was found to enhance shoulder function considerably (1). Breast cancer is the most common type of cancer in women and the leading cause of death and morbidity (2). Every year, 1.67 million new instances of breast cancer are identified worldwide, with 458,000 fatalities (2). Although 89 percent of breast cancer survivors live for at least five years after treatment, side symptoms can continue for months or even years(2). The most common upper-limb side effects are pain and joint dysfunction, with prevalence rates ranging from 12% to 51% for pain and 1.5 percent to 50% for joint dysfunction. Surgery is the most common treatment for primary breast cancer. Shoulder exercises are commonly advised to reduce mobility and strength loss as well as prevent lymphedema. Several clinical services have been developed to help with shoulder range of motion rehabilitation and secondary lymphedema prevention(3). The goal of this study was to see how additional postoperative physiotherapy affected shoulder function after the initial postoperative healing period, especially when given for a longer period. Patients who have had a mastectomy are always at risk of getting shoulder pain and adhesive capsulitis, and they must take precautions (3).

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Cancer Treatment Reviews

Physiotherapy improves shoulder function after treatment in women with early breast cancer

2006 •

Judith Cave

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Tumori

Two Exercise Schemes In Postoperative Breast Cancer: Comparison of Effects on Shoulder Movement and Lymphatic Disturbance

2006 •

Sirlei Morais

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International Journal of Rehabilitation Research

The effect of preoperative exercise on upper extremity recovery following breast cancer surgery: a systematic review

2018 •

Jonas Sokolof

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Meeting abstracts from the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials (2024)

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